PFK15 |CAS:4382-63-2 Probechem Biochemicals

Chemical Structure : PFK15

CAS No.: 4382-63-2

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PFK15 (PFK015;PFK 015)

货号: PC-42915Not For Human Use, Lab Use Only.

PFK15 (PFK 015) is a potent, selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM against recombinant human PFKFB3, displays 100-fold more activity than 3PO.

规格	价格	库存
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg	￥2980	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

PFK15 (PFK 015) is a potent, selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM against recombinant human PFKFB3, displays 100-fold more activity than 3PO.
PFK15 (PFK 015) does not inhibit PFK-1, hexokinase, phosphoglucose isomerase and PFKFB4, and has no activity against a panel of 96 kinases.
PFK15 (PFK 015) inhibits cancer cell viability (H522 cell IC50=0.72 uM) and induces apoptosis.
PFK15 (PFK 015) suppresses the glucose uptake and exhibits antitumor effects in human xenograft models.

物理化学性质&存储条件

分子量	260.29
分子式	C17H12N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 25.2 mg/mL
Chemical Name/SMILES	2-Propen-1-one, 1-(4-pyridinyl)-3-(2-quinolinyl)-

参考文献

1. Clem BF, et al. Mol Cancer Ther. 2013 Aug;12(8):1461-70.

2. Lea MA, et al. Anticancer Res. 2016 Apr;36(4):1479-88.

3. Zhu W, et al. PLoS One. 2016 Sep 26;11(9):e0163768.

4. Li HM, et al. J Exp Clin Cancer Res. 2017 Jan 7;36(1):7.

PFK15 (PFK015;PFK 015)

生物&药学活性

物理化学性质&存储条件

参考文献

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PFK15 (PFK015;PFK 015)

生物&药学活性

物理化学性质&存储条件

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