欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-E3 Ubiquitin Ligase-PFI-7
PFI-7

Chemical Structure : PFI-7

CAS No.: 2910938-58-6

加入收藏

PFI-7 (PFI 7, PFI7)

货号: PC-22417Not For Human Use, Lab Use Only.

PFI-7 is a potent, selective and cell-active chemical probe inhibitor for GID4, a substrate-binding receptor within the C-terminal to LisH (CTLH) E3 ligase complex.

规格 价格 库存 数量
25 mg Get quote
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

PFI-7 is a potent, selective and cell-active chemical probe inhibitor for Glucose-Induced Degradation 4 (GID4), the substrate receptor of the CTLH ubiquitin ligase complex, antagonizes Pro/N-degron binding to human GID4 with SPR Kd of 79 nM.
PFI-7 can directly displace the Pro/N-degron peptide PGLWKS from the GID4-binding pocket in a peptide displacement assay (Kdisp=4.1 uM).
PFI-7 binds within the β-barrel of GID4 substrate binding pocket, disrupting its interaction with the canonical Pro/N-degron peptide in cells.
PFI-7 decreases GID4-HaloTag binding to PGLKWS-NanoLuc on human embryonic kidney 293T (HEK293T) cells with IC50 of 0.54 uM.
PFI-7 is a suitable tool compound for use in cellular studies to interrogate GID4-mediated recruitment to the CTLH complex.
The Pro/N-degron pathway is a recently identified pathway that recognizes N-terminal degrons containing unmodified Proline residues (Pro/N-degrons).

物理化学性质&存储条件

分子量 401.51
分子式 C24H27N5O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Acetamide, N-[cis-4-(1H-benzimidazol-2-yl)cyclohexyl]-2-[(1H-indol-2-ylmethyl)amino]-

参考文献

1. Owens DDG, et al. Nat Chem Biol. 2024 May 21. doi: 10.1038/s41589-024-01618-0.

2. Yazdi AK, et al. RSC Med Chem. 2024 Mar 5;15(3):1066-1071.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: