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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Monoamine Oxidase (MAO)-PF9601N
PF9601N

Chemical Structure : PF9601N

CAS No.: 133845-63-3

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PF9601N (FA-73)

货号: PC-38442Not For Human Use, Lab Use Only.

PF9601N (FA-73) is a potent and selective, non-amphetamine type monoamine oxidase B (MAO-B) inhibitor with Ki of 0.75 and 800 nM for MAO-B and MAO-A, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PF9601N (FA-73) is a potent and selective, non-amphetamine type monoamine oxidase B (MAO-B) inhibitor with Ki of 0.75 and 800 nM for MAO-B and MAO-A, respectively.
PF9601N (FA-73) displays 1066 fold selectivity over MAO-A, and 48 times more selective than L-deprenyl.
PF9601N (FA-73) potently inhibits dopamine uptake in human caudate tissue with IC50 of 0.36 uM.
PF9601N (FA-73) inhibits mouse brain MAO-B activity about 90% ex vivo inhibited by after 4 mg kg(-1) administration, with no effect on MAO-A.
PF9601N (FA-73) significantly reduced MPP(+)-induced caspase-2 activity and PUMA-alpha levels in SH-SY5Y human dopaminergic cells.
PF9601N (FA-73) has shown neuroprotective properties in vivo using different experimental models of Parkinson's disease.

物理化学性质&存储条件

分子量 290.366
分子式 C19H18N2O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-(phenylmethoxy)-N-2-propyn-1-yl-1H-indole-2-methanamine

参考文献

1. Sanz E, et al. J Neurochem. 2008 Jun 1;105(6):2404-17.

2. Sanz E, et al. Mol Cell Neurosci. 2009 May;41(1):19-31.

3. Bolea I, et al. CNS Neurosci Ther. 2014 Jul;20(7):641-50.

4. V Pérez, et al. Br J Pharmacol. 1999 Jun;127(4):869-76.

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