PF 5212372 |CAS:916136-25-9 Probechem Biochemicals

Chemical Structure : PF 5212372

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PF 5212372 (PLA-950;ZPL-521;ZPL 5212372)

货号: PC-61846Not For Human Use, Lab Use Only.

PF 5212372 (PLA-950, ZPL-521, ZPL 5212372) is a potent, selective inhibitor of cPLA2 (cytosolic phospholipase A2α) with IC50 of 7 nM.

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生物&药学活性

PF 5212372 (PLA-950, ZPL-521, ZPL 5212372) is a potent, selective inhibitor of cPLA2 (cytosolic phospholipase A2α) with IC50 of 7 nM.
PF 5212372 inhibits PGD2 and cysteinyl leukotriene release from anti-IgE-stimulated human lung mast cells with IC50 of 0.29 and 0.45 nM, respectively.
PF 5212372 inhibits ionomycin-stimulated release of leukotriene B(4), thromboxane A(2), and PGD(2) (IC50 2.6, 2.6, and 4.0 nM, respectively).
PF 5212372 significantly inhibits AMP-induced contraction of human bronchi.

物理化学性质&存储条件

分子量	823.35
分子式	C42H38ClF3N2O6S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[[2-[5-Chloro-1-(diphenylmethyl)-2-[2-[[[[2-(trifluoromethyl)phenyl]methyl]sulfonyl]amino]ethyl]-1H-indol-3-yl]ethyl]sulfonyl]benzenepropanoic acid

参考文献

1. Hewson CA, et al. J Pharmacol Exp Ther. 2012 Mar;340(3):656-65.

2. McKew JC, et al. J Med Chem. 2008 Jun 26;51(12):3388-413.

PF 5212372 (PLA-950;ZPL-521;ZPL 5212372)

生物&药学活性

物理化学性质&存储条件

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PF 5212372 (PLA-950;ZPL-521;ZPL 5212372)

生物&药学活性

物理化学性质&存储条件

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