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首页-小分子抑制剂&激动剂-GPCR-mGluR-PF470
PF470

Chemical Structure : PF470

CAS No.: 1539296-45-1

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PF470 (PF-470)

货号: PC-61059Not For Human Use, Lab Use Only.

PF470 is a highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator with Ki of 0.9 nM, IC50 of 2.5 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    PF470 is a highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator with Ki of 0.9 nM, IC50 of 2.5 nM.
    PF470 demonstrates robust efficacy in MPTP-rendered Parkinsonian nonhuman primate model of l-DOPA-induced dyskinesia (PD-LID), but with delayed-type immune-mediated type IV hypersensitivity.

    物理化学性质&存储条件

    分子量 332.367
    分子式 C18H16N6O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1H-pyrazolo[3,4-b]pyrazine

    参考文献

    1. Zhang L, et al. J Med Chem. 2014 Feb 13;57(3):861-77.

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