PF 05180999 |CAS:1394033-54-5 Probechem Biochemicals

Chemical Structure : PF 05180999

CAS No.: 1394033-54-5

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PF 05180999 (PF-05180999;PF05180999;PF 5180999)

货号: PC-60564Not For Human Use, Lab Use Only.

PF-05180999 (PF 5180999) is a potent, selective, brain-penetrating and orally bioavailable phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 1 nM.

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10 mg	￥1480	In stock
25 mg	￥2480	In stock
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100 mg		Get quote

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生物&药学活性

PF-05180999 (PF 5180999) is a potent, selective, brain-penetrating and orally bioavailable phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 1 nM.
PF-05180999 displays >1,000-fold selectivity over PDE10.
PF-05180999 shows potential for treatment of schizophrenia.

物理化学性质&存储条件

分子量	414.396
分子式	C19H17F3N8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(1-Azetidinyl)-7-methyl-5-[1-methyl-5-[5-(trifluoromethyl)-2-pyridinyl]-1H-pyrazol-4-yl]-imidazo[5,1-f][1,2,4]triazine

参考文献

1. Mikami S, et al. J Med Chem. 2017 Sep 28;60(18):7677-7702.

2. Helal CJ, et al. J Med Chem. 2018 Jan 2. doi: 10.1021/acs.jmedchem.7b01466.

PF 05180999 (PF-05180999;PF05180999;PF 5180999)

生物&药学活性

物理化学性质&存储条件

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PF 05180999 (PF-05180999;PF05180999;PF 5180999)

生物&药学活性

物理化学性质&存储条件

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