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首页-小分子抑制剂&激动剂-Others-Other Targets-PF-DcpSi
PF-DcpSi

Chemical Structure : PF-DcpSi

CAS No.: 2092917-19-4

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PF-DcpSi (DcpS inhibitor)

货号: PC-60223Not For Human Use, Lab Use Only.

PF-DcpSi is a potent inhibitor of the mRNA decapping scavenger enzyme (DcpS) with IC50 of 0.11 nM.

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5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PF-DcpSi is a potent inhibitor of the mRNA decapping scavenger enzyme (DcpS) with IC50 of 0.11 nM.
PF-DcpSi shows no significant activity for DHFR (IC50>30 uM).
PF-DcpSi has in vivo mouse CNS PK profile, shows activity in SMA mouse model by prolonging survival and improving function thereby ruling out lysosomotropism.

物理化学性质&存储条件

分子量 309.304
分子式 C16H12FN5O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-((2,4-diaminoquinazolin-5-yl)methoxy)-5-fluorobenzonitrile

参考文献

1. Gopalsamy A, et al. J Med Chem. 2017 Apr 13;60(7):3094-3108.

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