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首页-小分子抑制剂&激动剂-Others-Other Targets-PF-DcpSi
PF-DcpSi

Chemical Structure : PF-DcpSi

CAS No.: 2092917-19-4

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PF-DcpSi (DcpS inhibitor)

货号: PC-60223Not For Human Use, Lab Use Only.

PF-DcpSi is a potent inhibitor of the mRNA decapping scavenger enzyme (DcpS) with IC50 of 0.11 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    PF-DcpSi is a potent inhibitor of the mRNA decapping scavenger enzyme (DcpS) with IC50 of 0.11 nM.
    PF-DcpSi shows no significant activity for DHFR (IC50>30 uM).
    PF-DcpSi has in vivo mouse CNS PK profile, shows activity in SMA mouse model by prolonging survival and improving function thereby ruling out lysosomotropism.

    物理化学性质&存储条件

    分子量 309.304
    分子式 C16H12FN5O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-((2,4-diaminoquinazolin-5-yl)methoxy)-5-fluorobenzonitrile

    参考文献

    1. Gopalsamy A, et al. J Med Chem. 2017 Apr 13;60(7):3094-3108.

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