PF-AKT400 |CAS:1004990-28-6 Probechem Biochemicals

Chemical Structure : PF-AKT400

CAS No.: 1004990-28-6

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PF-AKT400 (AKT protein kinase inhibitor)

货号: PC-42697Not For Human Use, Lab Use Only.

PF-AKT400 is a broadly selective, potent, ATP-competitive Akt kinase inhibitor with IC50 of 0.5 nM (biochemical assay), and 0.31 nM (cell function assay).

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5 mg	￥2580	In stock
10 mg	￥3880	In stock
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生物&药学活性

PF-AKT400 is a broadly selective, potent, ATP-competitive Akt kinase inhibitor with IC50 of 0.5 nM (biochemical assay), and 0.31 nM (cell function assay).
PF-AKT400 shows >900-fold selectivity over PKA.
PF-AKT400 shows excellent PK profiles and effective in in vivo models of xenograft tumor.

物理化学性质&存储条件

分子量	400.4251
分子式	C20H22F2N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, N-[[(3S)-3-amino-1-(5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3-pyrrolidinyl]methyl]-2,4-difluoro-

参考文献

1. Freeman-Cook KD, et al. J Med Chem. 2010 Jun 24;53(12):4615-22.

2. Chen SF, et al. J Mol Model. 2013 Nov;19(11):5097-112.

PF-AKT400 (AKT protein kinase inhibitor)

生物&药学活性

物理化学性质&存储条件

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PF-AKT400 (AKT protein kinase inhibitor)

生物&药学活性

物理化学性质&存储条件

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