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首页-小分子抑制剂&激动剂-Others-Other Targets-PF-9366
PF-9366

Chemical Structure : PF-9366

CAS No.: 72882-78-1

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PF-9366 (PF9366)

货号: PC-62311Not For Human Use, Lab Use Only.

PF-9366 is a novel selective, allosteric methionine adenosyltransferase 2A (Mat2A) inhibitor with IC50 of 420 nM, Kd of 170 nM.

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5 mg ￥1280 In stock
10 mg ￥1880 In stock
25 mg ￥2980 In stock
50 mg ￥4580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PF-9366 is a novel selective, allosteric methionine adenosyltransferase 2A (Mat2A) inhibitor with IC50 of 420 nM, Kd of 170 nM.
PF-9366 shows no substantial off-target activity in a functional panel of representative GPCRs, neurotransporters, phosphodiesterases, and ion channels;.
PF-9366 inhibits cellular SAM production with an IC50 of 255 nM in Huh-7 cells.

物理化学性质&存储条件

分子量 350.85
分子式 C20H19ClN4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

7-Chloro-N,N-dimethyl-5-phenyl[1,2,4]triazolo[4,3-a]quinoline-1-ethanamine

参考文献

1. Quinlan CL, et al. Nat Chem Biol. 2017 Jul;13(7):785-792.

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