PF-739 (PF739) | AMPK activator | Probechem Biochemicals

Chemical Structure : PF-739

CAS No.: 1852452-14-2

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PF-739 (PF 739, PF739)

货号: PC-60138Not For Human Use, Lab Use Only.

PF-739 (PF739) is a potent, pan-AMPK activator with similar potency for all AMPK heterotrimers, increases the phosphorylation of the AMPK substrate ACC at S79 with EC50 of 121 nM.

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生物&药学活性

PF-739 (PF739) is a potent, pan-AMPK activator with similar potency for all AMPK heterotrimers, increases the phosphorylation of the AMPK substrate ACC at S79 with EC50 of 121 nM.
PF-739 potently inhibits de novo lipogenesis (IC50=25 nM) in primary rat hepatocytes.
PF-739 increases PGC1a transcription and mitochondrial content, effectively activats AMPK in hepatocytes and in skeletal muscle.
PF-739 treatment caused a rapid lowering of plasma glucose levels with no impact on hepatic glucose production in diabetic mice.

物理化学性质&存储条件

分子量	442.896
分子式	C23H23ClN2O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3R,3aR,6R,6aR)-6-((6-chloro-5-(4-(1-(hydroxymethyl)cyclopropyl)phenyl)-1Hbenzo[d]imidazol-2-yl)oxy)hexahydrofuro[3,2-b]furan-3-ol

参考文献

1. Cokorinos EC, et al. Cell Metab. 2017 May 2;25(5):1147-1159.

PF-739 (PF 739, PF739)

生物&药学活性

物理化学性质&存储条件

参考文献

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PF-739 (PF 739, PF739)

生物&药学活性

物理化学性质&存储条件

参考文献

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