PF-719 | Pyk2 inhibitor | Probechem Biochemicals

Chemical Structure : PF-719

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PF-719 (PF719)

货号: PC-22150Not For Human Use, Lab Use Only.

PF-719 (PF719) is a potent, selective Pyk2 inhibitor with IC50 of 17 nM, displays 25-fold selectvity over FAK (IC50=469 nM).

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生物&药学活性

PF-719 (PF719) is a potent, selective Pyk2 inhibitor with IC50 of 17 nM, displays 25-fold selectvity over FAK (IC50=469 nM).
PF-719 does not have significant inhibitory effects on recombinant MLCK2, p38, Akt1, or ROCK1, and very little inhibtion at Src family kinases (IC50>5 uM).
PF-719 selectively inhibits tyrosine phosphorylation of Pyk2 at 1 uM, but blocks both Pyk2 and FAK phosphorylation at 2.5 uM in A20 cells.
PF-719 reduces chemoattractant-induced migration of B-2 and MZ B cells.

物理化学性质&存储条件

分子量	448.49
分子式	C22H27F3N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-cyclopropyl-4-(4-((1R,2R)-2-(dimethylamino)cyclopentylamino)-5-(trifluoromethyl)pyrimidin2-ylamino)benzamide

参考文献

1. Tse KW, et al. Cell Immunol. 2012 Jan-Feb;275(1-2):47-54.

PF-719 (PF719)

生物&药学活性

物理化学性质&存储条件

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PF-719 (PF719)

生物&药学活性

物理化学性质&存储条件

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