PF-7006 | MPS1/TTK inhibitor | Probechem Biochemicals

Chemical Structure : PF-7006

加入收藏

PF-7006 (PF7006)

货号: PC-21557Not For Human Use, Lab Use Only.

PF-7006 is a potent, highly-selective Mps1 (TTK) inhibitor with Ki of 0.27 nM, potently inhibit Mps1 in MDA-MB-468 tumor cells with IC50 of 2.5 nM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

PF-7006 is a potent, highly-selective Mps1 (TTK) inhibitor with Ki of 0.27 nM, potently inhibit Mps1 in MDA-MB-468 tumor cells with IC50 of 2.5 nM.
PF-7006 triggers signaling events consistent with mitotic checkpoint abrogation.
PF-7006 at 25 mg/kg inhibited tuomor growth in the HCC1806 triple-negative breast cancer model.
PF-7006 inhibitor-induced cytotoxicity as function of retinoblastoma tumor suppressor protein (Rb1) status in tHMEC cultures co-treated with the CDK4/6 inhibitor palabociclib.
PF-7006 is shown to be selectively cytotoxic to Rb1-deficient cells relative to Rb1-competent cells.

物理化学性质&存储条件

分子量	434.50
分子式	C22H26N8O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((2-methyl-6-morpholinopyridin-3-yl)amino)-4-((tetrahydro-2H-pyran-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

参考文献

1. Ricardo Martinez, et al. PLoS One. 2015 Sep 23;10(9):e0138616.

PF-7006 (PF7006)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

PF-7006 (PF7006)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.