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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Breast Tumor Kinase (BRK;PTK6)-PF-6689840
PF-6689840

Chemical Structure : PF-6689840

CAS No.: 1799790-53-6

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PF-6689840 (PF6689840)

货号: PC-35188Not For Human Use, Lab Use Only.

PF-6689840 (PF6689840) is a potent and selective Type II PTK6/Brk inhibitor with IC50 of 54 nM in biochemical assays.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    PF-6689840 (PF6689840) is a potent and selective Type II PTK6/Brk inhibitor with IC50 of 54 nM in biochemical assays。
    PF-6689840 inhibits PTK6 phosphorylation at Y342 in engineered HET293T cells overexpressing PTK6 WT with IC50 of 0.25 uM。
    PF-6689840 demonstrates superior kinase selectivity compared to the Type I inhibitors; inhibits tumor cell growth, which is independent of PTK6 expression levels in cells.

    物理化学性质&存储条件

    分子量 521.473
    分子式 C24H23F4N5O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(((3R,4R)-3-fluoro-1-(2-(4-(trifluoromethoxy)phenyl)acetyl)piperidin-4-yl)oxy)-5-(1-methyl-1H-imidazol-4-yl)nicotinamide

    参考文献

    1. Qiu L, et al. PLoS One. 2018 Jun 7;13(6):e0198374.

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