PF-6683324 |CAS:1799788-94-5 Probechem Biochemicals

首页-小分子抑制剂&激动剂-Tyrosine Kinase-Breast Tumor Kinase (BRK;PTK6)-PF-6683324

Chemical Structure : PF-6683324

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PF-6683324 (PF6683324)

货号: PC-35187Not For Human Use, Lab Use Only.

PF-6683324 (PF6683324) is a potent and selective Type II PTK6/Brk inhibitor with IC50 of 76 nM in biochemical assays.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PF-6683324 (PF6683324) is a potent and selective Type II PTK6/Brk inhibitor with IC50 of 76 nM in biochemical assay.
PF-6683324 inhibits PTK6 phosphorylation at Y342 in engineered HET293T cells overexpressing PTK6 WT with IC50 of 0.7 uM。
PF-6683324 demonstrates superior kinase selectivity compared to the Type I inhibitors.

物理化学性质&存储条件

分子量	521.473
分子式	C24H23F4N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(((3S,4R)-3-fluoro-1-(2-(4-(trifluoromethoxy)phenyl)acetyl)piperidin-4-yl)oxy)-5-(1-methyl-1H-imidazol-4-yl)nicotinamide

参考文献

1. Qiu L, et al. PLoS One. 2018 Jun 7;13(6):e0198374.

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PF-6683324 (PF6683324)

生物&药学活性

物理化学性质&存储条件

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PF-6683324 (PF6683324)

生物&药学活性

物理化学性质&存储条件

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