PF-543 |CAS:1415562-82-1 Probechem Biochemicals

Chemical Structure : PF-543

CAS No.: 1415562-82-1

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PF-543 (PF543;PF 543)

货号: PC-35528Not For Human Use, Lab Use Only.

PF-543 (PF543) is a potent, specific, cell-permeant inhibitor of SphK1 with Ki of 3.6 nM, displays >100-fold selectivity over the SphK2 isoform.

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10 mg	￥1580	In stock
25 mg	￥2580	In stock
50 mg	￥3980	In stock
100 mg		Get quote

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生物&药学活性

PF-543 (PF543) is a potent, specific, cell-permeant inhibitor of SphK1 with Ki of 3.6 nM, displays >100-fold selectivity over the SphK2 isoform.
PF-543 decreases the level of endogenous S1P 10-fold with a proportional increase in the level of sphingosine in 1483 head and neck carcinoma cells.
PF-543 reduces sickling, hemolysis, and inflammation in SCD Tg mice by reducing erythrocyte SPHK1 activity and S1P levels.
PF-543 induces apoptosis, necrosis, and autophagy in human head and neck SCC cells.

物理化学性质&存储条件

分子量	465.608
分子式	C27H31NO4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R)-1-[[4-[[3-Methyl-5-[(phenylsulfonyl)methyl]phenoxy]methyl]phenyl]methyl]-2-pyrrolidinemethanol

参考文献

1. Hamada M, et al. Cell Death Discov. 2017 Aug 14;3:17047.

2. Schnute ME, et al. Biochem J. 2012 May 15;444(1):79-88.

3. Zhang Y, et al. J Clin Invest. 2014 Jun;124(6):2750-61.

4. Wang J, et al. ACS Med Chem Lett. 2014 Oct 27;5(12):1329-33.

PF-543 (PF543;PF 543)

生物&药学活性

物理化学性质&存储条件

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PF-543 (PF543;PF 543)

生物&药学活性

物理化学性质&存储条件

参考文献

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