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PF-5081090

Chemical Structure : PF-5081090

CAS No.: 1312473-63-4

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PF-5081090 (LpxC-4, PF5081090)

货号: PC-26543Not For Human Use, Lab Use Only.

PF-5081090 (LpxC-4) is a highly potent LpxC inhibitor with IC50 of 1.1 nM (P. aeruginosa LpxC) and MIC90 of 1 ug/mL, inhibits lipid A biosynthesis and is synergistic with azithromycin, rifampin, or vancomycin for multidrug-resistant A. baumannii.

规格 价格 库存 数量
5 mg ￥1980 In stock
10 mg ￥3280 In stock
25 mg ￥5480 In stock
50 mg Get quote
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PF-5081090 (LpxC-4) is a highly potent LpxC inhibitor with IC50 of 1.1 nM (P. aeruginosa LpxC) and MIC90 of 1 ug/mL, inhibits lipid A biosynthesis and is synergistic with azithromycin, rifampin, or vancomycin for multidrug-resistant A. baumannii.

物理化学性质&存储条件

分子量 412.43
分子式 C18H21FN2O6S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-4-(4-(2-Fluoro-4-methoxyphenyl)-2-oxopyridin-1(2H)-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide

参考文献

1. García-Quintanilla M, et al. Antimicrob Agents Chemother. 2016 Jul 22;60(8):5076-9.

2. Niu Z, et al. Eur J Med Chem. 2023 May 5;253:115326.

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