PF-4950834 |CAS:1256264-62-6 Probechem Biochemicals

Chemical Structure : PF-4950834

CAS No.: 1256264-62-6

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PF-4950834 (PF4950834;PF 4950834)

货号: PC-60681Not For Human Use, Lab Use Only.

PF-4950834 is a potent, selective, ATP-competitive and orally acitve Rho kinase (ROCK) inhibitor with IC50 of 33.1 and 8.5 nM for ROCK1 and ROCK2, respectively.

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10 mg	￥3580	In stock
25 mg	￥5580	In stock
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生物&药学活性

PF-4950834 is a potent, selective, ATP-competitive and orally acitve Rho kinase (ROCK) inhibitor with IC50 of 33.1 and 8.5 nM for ROCK1 and ROCK2, respectively.
PF-4950834 displays 5-140-fold selectivity over other AGC kinase family.
PF-4950834 inhibits Jurkat T cell migration with IC50 of 68.4 nM, suppresses activation of both LPA- and thrombin-mediated activation of Rho kinase, and blocked both LPA-induced and thrombin-induced expression of ICAM-1 and VCAM-1 in HUVECs.
PF-4950834 attenuates leukocyte migration in vivo.

物理化学性质&存储条件

分子量	345.402
分子式	C21H19N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-methyl-3-{[(4-pyridin-4-ylbenzoyl)amino]methyl}benzamide

参考文献

1. Rajagopalan LE, et al. J Pharmacol Exp Ther. 2010 Jun;333(3):707-16.

PF-4950834 (PF4950834;PF 4950834)

生物&药学活性

物理化学性质&存储条件

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PF-4950834 (PF4950834;PF 4950834)

生物&药学活性

物理化学性质&存储条件

参考文献

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