PF-4778574 |CAS:1219633-99-4 Probechem Biochemicals

Chemical Structure : PF-4778574

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PF-4778574 (PF4778574;PF 4778574)

货号: PC-35556Not For Human Use, Lab Use Only.

PF-4778574 (PF4778574) is a brain penetrant, positive allosteric modulator (potentiator) of AMPA receptor with Ki of 85 nM, increases S-AMPA-evoked responses in rat primary cortical neurons with EC50 of 45-919 nM.

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生物&药学活性

PF-4778574 (PF4778574) is a brain penetrant, positive allosteric modulator (potentiator) of AMPA receptor with Ki of 85 nM, increases S-AMPA-evoked responses in rat primary cortical neurons with EC50 of 45-919 nM.
PF-4778574 robustly ameliorates ketamine-induced working memory impairments in vivo.

物理化学性质&存储条件

分子量	390.516
分子式	C19H22N2O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-{(3R,4S)-3-[4-(5-cyano-2-thienyl)phenyl]tetrahydro-2H-pyran-4-yl}propane-2-sulfonamide

参考文献

1. Shaffer CL, et al. J Pharmacol Exp Ther. 2013 Oct;347(1):212-24.

2. Roberts BM, et al. Behav Brain Res. 2010 Sep 1;212(1):41-8.

PF-4778574 (PF4778574;PF 4778574)

生物&药学活性

物理化学性质&存储条件

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PF-4778574 (PF4778574;PF 4778574)

生物&药学活性

物理化学性质&存储条件

参考文献

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