PF-46396 |CAS:1207481-21-7 Probechem Biochemicals

Chemical Structure : PF-46396

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PF-46396 (PF 46396;PF46396)

货号: PC-60408Not For Human Use, Lab Use Only.

PF-46396 is a specific small-molecule inhibitor of HIV-1 Gag maturation that interferes specifically with the cleavage of the CA/SP1 (p25) Gag precursor to the mature CA (p24) protein.

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生物&药学活性

PF-46396 is a specific small-molecule inhibitor of HIV-1 Gag maturation that interferes specifically with the cleavage of the CA/SP1 (p25) Gag precursor to the mature CA (p24) protein.
PF-46396 exhibits antiviral activity against 17/27 HIV-1 clinical isolates with EC50s ranging from 0.005 to 7 uM and TI values ranging from 2 to 3,400.

物理化学性质&存储条件

分子量	454.537
分子式	C27H29F3N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-[2-(4-tert-butylphenyl)-2-(2,3-dihydro-1H-inden-2-ylamino)ethyl]-3-(trifluoromethyl)pyridin-2-one

参考文献

1. Blair WS, et al. Antimicrob Agents Chemother. 2009 Dec;53(12):5080-7.

2. Murgatroyd C, et al. J Virol. 2016 Aug 26;90(18):8181-97.

3. Waki K, et al. PLoS Pathog. 2012;8(11):e1002997.

PF-46396 (PF 46396;PF46396)

生物&药学活性

物理化学性质&存储条件

参考文献

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PF-46396 (PF 46396;PF46396)

生物&药学活性

物理化学性质&存储条件

参考文献

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