PF-3644022 |Cas:1276121-88-0 Buy PF-3644022 from ProbeChem, Global Biochemicals Supplier

Chemical Structure : PF-3644022

CAS No.: 1276121-88-0

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PF-3644022 (PF 3644022;PF3644022)

货号: PC-70143Not For Human Use, Lab Use Only.

PF-3644022 is a potent and selective, freely reversible, ATP-competitive inhibitor of MAPKAP2 (MK2) with Ki of 3 nM.

规格	价格	库存
5 mg	￥2480	In stock
10 mg	￥3980	In stock
25 mg	￥5880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

PF-3644022 is a potent and selective, freely reversible, ATP-competitive inhibitor of MAPKAP2 (MK2) with Ki of 3 nM.
PF-3644022 shows good selectivity against a panel of 200 human kinases.
PF-3644022 potently inhibits TNFα production with similar activity (IC50=160 nM) in U937 cells and hPBMCs, blocks TNFα and IL-6 production in LPS-stimulated human whole blood with IC50 of 1.6 and 10.3 uM, respectively.
PF-3644022 is activite in the rat LPS-induced TNFalpha model and orally efficacious.

物理化学性质&存储条件

分子量	374.46
分子式	C21H18N4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	100 mM in DMSO (37.4 mg/mL)
Chemical Name/SMILES	(10R)-9,10,11,12-Tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one

参考文献

1. Mourey RJ, et al. J Pharmacol Exp Ther. 2010 Jun;333(3):797-807.

2. Song H, et al. Am J Transl Res. 2015 Nov 15;7(11):2355-63.

PF-3644022 (PF 3644022;PF3644022)

生物&药学活性

物理化学性质&存储条件

参考文献

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PF-3644022 (PF 3644022;PF3644022)

生物&药学活性

物理化学性质&存储条件

参考文献

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