PF-3450074 |CAS:1352879-65-2 Probechem Biochemicals

Chemical Structure : PF-3450074

CAS No.: 1352879-65-2

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PF-3450074 (PF3450074;PF-74;PF74)

货号: PC-63542Not For Human Use, Lab Use Only.

PF-3450074 (PF74) is a small molecule HIV capsid protein, destabilized the viral capsid in vitro.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2180	In stock
100 mg	￥3780	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

PF-3450074 (PF74) is a small molecule HIV capsid protein, destabilized the viral capsid in vitro.
PF-3450074 (PF74) acts at an early stage of HIV-1 infection and inhibits reverse transcription in target cells, induced the rapid dissolution of the HIV-1 capsid.
PF-3450074 (PF74) antiviral activity is promoted by binding of the host protein cyclophilin A to the HIV-1 capsid, and PF74 and cyclosporine exhibited mutual antagonism.

物理化学性质&存储条件

分子量	425.532
分子式	C27H27N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Methyl-N-[(1S)-2-(methylphenylamino)-2-oxo-1-(phenylmethyl)ethyl]- 1H-indole-3-acetamide

参考文献

1. Shi J, et al. J Virol. 2011 Jan;85(1):542-9.

2. Shi J, et al. J Virol. 2015 Jan;89(1):208-19.

3. Zhou J, et al. J Virol. 2015 Sep;89(17):9068-79.

4. Saito A, et al. J Virol. 2016 May 27;90(12):5808-5823.

PF-3450074 (PF3450074;PF-74;PF74)

生物&药学活性

物理化学性质&存储条件

参考文献

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PF-3450074 (PF3450074;PF-74;PF74)

生物&药学活性

物理化学性质&存储条件

参考文献

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