PF-232798 |CAS:849753-15-7 Probechem Biochemicals

Chemical Structure : PF-232798

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PF-232798 (PF232798;PF-00232798)

货号: PC-61582Not For Human Use, Lab Use Only.

PF-232798 (PF-00232798) is a potent CCR5 antagonist with IC50 of <0.1 nM in gp160 fusion assay, exhibits potent broad-spectrum anti-HIV-1 activity.

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生物&药学活性

PF-232798 (PF-00232798) is a potent CCR5 antagonist with IC50 of <0.1 nM in gp160 fusion assay, exhibits potent broad-spectrum anti-HIV-1 activity.
PF-232798 shows no significant affinity for hERG (binding IC50>12 uM); demonstrates antiviral activity against HIV BaL in PBMCs with IC50 of 2.0 nM.

物理化学性质&存储条件

分子量	509.67
分子式	C29H40FN5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-{(1S)-1-(3-fluorophenyl)-3-[(3-endo)-3-(5-isobutyryl-2-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}acetamide

参考文献

1. Stupple PA, et al. J Med Chem. 2011 Jan 13;54(1):67-77.

2. Abrol R, et al. Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13040-5.

PF-232798 (PF232798;PF-00232798)

生物&药学活性

物理化学性质&存储条件

参考文献

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PF-232798 (PF232798;PF-00232798)

生物&药学活性

物理化学性质&存储条件

参考文献

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