PF-152 | MMP13 inhibitor | Probechem Biochemicals

Chemical Structure : PF-152

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PF-152 (PF152)

货号: PC-61148Not For Human Use, Lab Use Only.

PF-152 is a potent, highly selective and orally bioavailable MMP13 inhibitor with Ki of 1.5 nM, with no activity against MMP3 (Ki>10 uM).

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生物&药学活性

PF-152 is a potent, highly selective and orally bioavailable MMP13 inhibitor with Ki of 1.5 nM, with no activity against MMP3 (Ki>10 uM).
PF-152 also displays high selectivity against a panel of 14 matrix metalloproteinases, TACE, ADAMTS-4 and ADAMTS-5.
PF-152 suppresses MMP-13 mediated cartilage degradation in vivo, shows potential for treatment of oteoarthritis.

物理化学性质&存储条件

分子量	473.465
分子式	C21H24FN7O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-Fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide

参考文献

1. Ruminski PG, et al. J Med Chem. 2016 Jan 14;59(1):313-27.

2. Settle S, et al. Arthritis Rheum. 2010 Oct;62(10):3006-15.

PF-152 (PF152)

生物&药学活性

物理化学性质&存储条件

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PF-152 (PF152)

生物&药学活性

物理化学性质&存储条件

参考文献

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