欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Others-Other Targets-PF-07328948
PF-07328948

Chemical Structure : PF-07328948

CAS No.: 2936625-34-0

加入收藏

PF-07328948 (PF07328948)

货号: PC-23451Not For Human Use, Lab Use Only.

PF-07328948 is the first potent, selective branched-chain ketoacid dehydrogenase kinase (BDK or BCKDK) with in vitro IC50 of 15 nM, and cellular IC50 of 46 nM in human skeletal muscle BDK activity assay.

规格 价格 库存 数量
5 mg ￥3480 In stock
10 mg ￥5480 In stock
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PF-07328948 is the first potent, selective branched-chain ketoacid dehydrogenase kinase (BDK or BCKDK) with in vitro IC50 of 15 nM, and cellular IC50 of 46 nM in human skeletal muscle BDK activity assay.
PF-07328948 is not only a BDK inhibitor but also BDK degrader.
PF-07328948 shows a high degree of selectivity over a number of enzymes, receptors, and ion channels, as well as excellent kinase selectivity.
PF-07328948 binds to the BDK allosteric pocket and does not contain a traditional ATP-binding site motif.
PF-07328948 binds to BDK with SPR Kd of 4.8 nM.
PF-07328948 also destabilizes the interaction between BDK and E2.
PF-07328948 also shows high species potency against mouse BDK IC50 = 41 nM, rat BDK IC50 = 24 nM, and dog BDK IC50 = 24 nM. lowered plasma biomarkers, including BCAAs and branched-chain ketoacids (BCKAs) in vivo with enhanced pharmacodynamic effect upon chronic dosing due to BDK degradation.

物理化学性质&存储条件

分子量 356.29
分子式 C16H8F4O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-fluoro-3-(2,4,5-trifluoro-3-methoxyphenyl)benzo[b]thiophene-2-carboxylic acid

参考文献

1. Filipski KJ, et al. J Med Chem. 2024 Nov 19. doi: 10.1021/acs.jmedchem.4c02230.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: