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首页-新冠病毒相关-SARS-CoV-2 Inhibitors-PF-07304814
PF-07304814

Chemical Structure : PF-07304814

CAS No.: 2468015-78-1

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PF-07304814 (PF 07304814, Lufotrelvir)

货号: PC-72751Not For Human Use, Lab Use Only.

PF-07304814 (PF 07304814, Lufotrelvir) is a phosphate prodrug of PF-00835231, which is a potent, selective inhibitor of pan-coronavirus family 3CL pro.

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5 mg ￥1580 In stock
10 mg ￥2480 In stock
25 mg ￥4480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PF-07304814 (PF 07304814, Lufotrelvir) is a phosphate prodrug of PF-00835231, which is a potent, selective inhibitor of pan-coronavirus family 3CL pro.

物理化学性质&存储条件

分子量 552.521
分子式 C24H33N4O9P
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-3-((S)-2-(4-Methoxy-1H-indole-2-carboxamido)-4-methylpentanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butyl dihydrogen phosphate

参考文献

1. de Vries M, et al. J Virol. 2021 Feb 23;95(10):e01819-20.

2. Liu C, et al. Antiviral Res. 2021 Mar;187:105020.

3. Hoffman RL, et al. J Med Chem. 2020 Nov 12;63(21):12725-12747.

4. Robert L Hoffman, et al. J Med Chem. 2020 Nov 12;63(21):12725-12747.

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