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首页-小分子抑制剂&激动剂-Others-Other Targets-PF-07247685
PF-07247685

Chemical Structure : PF-07247685

CAS No.:

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PF-07247685 (PF 07247685)

货号: PC-21020Not For Human Use, Lab Use Only.

PF-07247685 (PF-07247685) is a potent, allosteric branched-chain ketoacid dehydrogenase kinase (BDK) inhibitor with in vitro IC50 of 0.86 nM, and SPR Kd of 0.68 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

PF-07247685 (PF-07247685) is a potent, allosteric branched-chain ketoacid dehydrogenase kinase (BDK) inhibitor with in vitro IC50 of 0.86 nM, and SPR Kd of 0.68 nM.
PF-07247685 exhibits potent inhibitory potency in human skeletal myocytes using an AlphaLISA SureFire Ultra detection system to monitor BCKDH phosphorylation (cellular IC50 =3.0  nM).
PF-07247685 demonstrates superior potency relative to BT2 (Cat. PC-49378, IC50=1100 nM in vitro).
PF-07247685 acutely lowers tissue BCAA/BCKA in HFD-fed mouse tissues, increases BDK protein levels.

物理化学性质&存储条件

分子量 380.46
分子式 C21H20N2O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(4-(6-((1-ethylcyclopropyl)methoxy)pyridin-3-yl)thiazol-2-yl)benzoic acid

参考文献

1. Rachel J Roth Flach, et al. Nat Commun. 2023 Aug 9;14(1):4812.

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