PF-07208254 | BDK inhibitor | Probechem Biochemicals

Chemical Structure : PF-07208254

CAS No.: 2573122-40-2

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PF-07208254 (PF 07208254)

货号: PC-21021Not For Human Use, Lab Use Only.

PF-07208254 (PF 07208254) is a potent, allosteric branched-chain ketoacid dehydrogenase kinase (BDK, BCKDK) inhibitor with in vitro IC50 of 110 nM and Ki of 54 nM.

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10 mg	￥5880	In stock
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生物&药学活性

PF-07208254 (PF 07208254) is a potent, allosteric branched-chain ketoacid dehydrogenase kinase (BDK, BCKDK) inhibitor with in vitro IC50 of 110 nM and Ki of 54 nM.
PF-07208254 exhibits potent inhibitory potency in human skeletal myocytes using an AlphaLISA SureFire Ultra detection system to monitor BCKDH phosphorylation (cellular IC50 = 540 nM).
PF-07208254 exhibits Kd value of 84 nM in surface plasmon resonance (SPR)-based binding assays.
PF-07208254 demonstrates superior potency relative to BT2 (Cat. PC-49378, IC50=1100 nM in vitro).
PF-07208254 (90 mg/kg) improves cardiac function and metabolism, reduces pBCKDH in mice.
PF-07208254 reduces pBCKDH and promotes BDK protein levels in human cells and in mice.

物理化学性质&存储条件

分子量	236.66
分子式	C7H2ClFO2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-chloro-5-fluorothieno[3,2-b]thiophene-2-carboxylic acid

参考文献

1. Rachel J Roth Flach, et al. Nat Commun. 2023 Aug 9;14(1):4812.

PF-07208254 (PF 07208254)

生物&药学活性

物理化学性质&存储条件

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PF-07208254 (PF 07208254)

生物&药学活性

物理化学性质&存储条件

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