Tegtociclib (PF-07104091, Tagtociclib) | CDK2 inhibitor

Chemical Structure : PF-07104091

CAS No.: 2460249-19-6

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PF-07104091 (Tegtociclib, PF 07104091)

货号: PC-20283Not For Human Use, Lab Use Only.

Tegtociclib (PF-07104091, Tagtociclib) is a highly potent CDK2-selective inhibitor with Ki of 1.16 nM, shows potential for the treatment of cyclinE-amplified cancers.

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10 mg	￥2980	In stock
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生物&药学活性

Tegtociclib (PF-07104091, Tagtociclib) is a highly potent CDK2-selective inhibitor with Ki of 1.16 nM, shows potential for the treatment of cyclinE-amplified cancers.
PF-07104091 displays 100-fold selectivity against CDK1, 200 to 400-fold selectivity against CDK4 and CDK6, 170-fold selectivity against CDK9, and greater than 500-fold selectivity against GSK3B.
PF-07104091 demonstrated a dose-dependent tumor growth reduction with 86 percent maximal effect in ovarian cancer model and demonstrated single-agent efficacy across multiple ovarian models.

物理化学性质&存储条件

分子量	404.47
分子式	C19H28N6O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,3S)-3-(3-(3-(methoxymethyl)-1-methyl-1H-pyrazole-5-carboxamido)-1H-pyrazol-5-yl)cyclopentyl isopropylcarbamate

参考文献

1. Hoffman, R. L., PF-07104091: A CDK2 selective inhibitor of cyclinE amplified cancers. In AACR Annual Meeting 2021, Session DDT02.

PF-07104091 (Tegtociclib, PF 07104091)

生物&药学活性

物理化学性质&存储条件

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PF-07104091 (Tegtociclib, PF 07104091)

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物理化学性质&存储条件

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