PF-07059013 | Hemoglobin modulator | Probechem Biochemicals

Chemical Structure : PF-07059013

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PF-07059013 (PF 07059013)

货号: PC-72609Not For Human Use, Lab Use Only.

PF-07059013 (PF 07059013) is a potent, noncovalent modulator of sickled hemoglobin (HbS), specifically binds to Hb with nanomolar affinity (Ki=0.6 nM) and displays strong partitioning into RBCs.

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生物&药学活性

PF-07059013 (PF 07059013) is a potent, noncovalent modulator of sickled hemoglobin (HbS), specifically binds to Hb with nanomolar affinity (Ki=0.6 nM) and displays strong partitioning into RBCs.
PF-07059013 showed concentration dependent blood binding in human blood, substantially decrease RBC sickling in vivo.
PF-07059013 has advanced to phase 1 clinical trials for treatment of sickle cell disease (SCD).

物理化学性质&存储条件

分子量	365.368
分子式	C19H16FN5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-6-(1-((2-Amino-6-fluoroquinolin-3-yl)oxy)ethyl)-5-(1H-pyrazol-1-yl)pyridin-2(1H)-one

参考文献

1. Gopalsamy A, et al. J Med Chem. 2021 Jan 14;64(1):326-342.

2. Knee KM, et al. Am J Hematol. 2021 Aug 1;96(8):E272-E275.

PF-07059013 (PF 07059013)

生物&药学活性

物理化学性质&存储条件

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PF-07059013 (PF 07059013)

生物&药学活性

物理化学性质&存储条件

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