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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Phosphodiesterase (PDE)-PF-07038124
PF-07038124

Chemical Structure : PF-07038124

CAS No.: 2415085-44-6

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PF-07038124 (PF 07038124)

货号: PC-20682Not For Human Use, Lab Use Only.

PF-07038124 (PF 07038124) is a highly potent, selective PDE4 inhibitor with IC50 of 0.5 nM for PDE4B2 in SPA assays, inhibits cytokines release of IL-4, IL-13 and IFNy from human PBMCs stimulated with PHA-L with IC50 of 135, 4.1, and 1.06 nM, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

PF-07038124 (PF 07038124) is a highly potent, selective PDE4 inhibitor with IC50 of 0.5 nM for PDE4B2 in SPA assays, inhibits cytokines release of IL-4, IL-13 and IFNy from human PBMCs stimulated with PHA-L with IC50 of 135, 4.1, and 1.06 nM, respectively.

物理化学性质&存储条件

分子量 327.19
分子式 C18H22BNO4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

CCCOC1=C(OC)C=CC(C2=CN=CC([C@@]3([H])CB(OC3)O)=C2)=C1

参考文献

1. Patent WO2020070651A1 (Example 4).

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