PF-06815189 |CAS: 2218484-75-2 Probechem Biochemicals

Chemical Structure : PF-06815189

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PF-06815189 (PF06815189)

货号: PC-62528Not For Human Use, Lab Use Only.

PF-06815189 is a potent, selective phosphodiesterase 2 (PDE2) inhibitor with IC50 of 0.4 nM, >1,000-fold selectivity over PDE5.

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生物&药学活性

PF-06815189 is a potent, selective phosphodiesterase 2 (PDE2) inhibitor with IC50 of 0.4 nM, >1,000-fold selectivity over PDE5.
PF-06815189 also demonstrates no significant activities (EC50 >10 μM) in a broad spectrum BioPrint panel.
PF-06815189 possesses favorable pharmacological and in vitro ADME profile, the pharmacokinetic attributes.

物理化学性质&存储条件

分子量	418.38
分子式	C19H17F3N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(1,3-dimethyl-5-(4-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)-5-(hydroxymethyl)-2-methylimidazo[5,1-f][1,2,4]triazin-4(3H)-one

参考文献

1. Stepan AF, et al. ACS Med Chem Lett. 2018 Jan 4;9(2):68-72.

PF-06815189 (PF06815189)

生物&药学活性

物理化学性质&存储条件

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PF-06815189 (PF06815189)

生物&药学活性

物理化学性质&存储条件

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