PF-06795071 | MAGL inhibitor | Probechem Biochemicals

Chemical Structure : PF-06795071

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PF-06795071 (PF06795071)

货号: PC-63525Not For Human Use, Lab Use Only.

PF-06795071 is a potent, selective, covalent Monoacylglycerol Lipase (MAGL) inhibitor with IC50 of 3 nM, >1,000-fold selectivity over FAAH.

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生物&药学活性

PF-06795071 is a potent, selective, covalent Monoacylglycerol Lipase (MAGL) inhibitor with IC50 of 3 nM, >1,000-fold selectivity over FAAH.
2075629-81-9 shows significant solubility improvements as compared with analogs with a similar profile, also exhibits excellent serine hydrolase selectivity and a clean in vitro safety profile.
2075629-81-9 shows good CNS exposure in mouse and a suitable PK profile for use as a tool to explore in vivo efficacy.

物理化学性质&存储条件

分子量	399.346
分子式	C18H17F4N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R)-1,1,1-Trifluoro-3-hydroxypropan-2-yl (1R,5S,6r)-6-[1-(4-Fluorophenyl)-1H-pyrazol-3-yl]-3-azabicyclo[3.1.0]hexane-3-carboxylate

参考文献

1. McAllister La, et al. J Med Chem. 2018 Apr 12;61(7):3008-3026.

PF-06795071 (PF06795071)

生物&药学活性

物理化学性质&存储条件

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PF-06795071 (PF06795071)

生物&药学活性

物理化学性质&存储条件

参考文献

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