PF-06761281 | NaCT inhibitor | Probechem Biochemicals

首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Sodium-coupled Citrate Transporter (NaCT,SLC13A5)-PF-06761281

Chemical Structure : PF-06761281

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PF-06761281 (PF 06761281, PF06761281)

货号: PC-61147Not For Human Use, Lab Use Only.

PF-06761281 is a potent, selective sodium-coupled citrate transporter (NaCT or SLC13A5) with IC50 of 0.51 uM, >20-fold selectivity over NaDC1 and NaDC3.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PF-06761281 is a potent, selective sodium-coupled citrate transporter (NaCT or SLC13A5) with IC50 of 0.51 uM, >20-fold selectivity over NaDC1 and NaDC3.
PF-06761281 demonstrates dose-dependent inhibition of radioactive [(14)C]citrate uptake in liver and kidney in vivo.
PF-06761281 reduces fasting plasma glucose concentrations with suitable in vivo pharmacokinetic profile.

物理化学性质&存储条件

分子量	283.28
分子式	C13H17NO6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-Hydroxy-2-(2-(2-methoxy-5-methylpyridin-3-yl)ethyl)-succinic Acid

参考文献

1. Huard K, et al. J Med Chem. 2016 Feb 11;59(3):1165-75.

2. Rives ML, et al. Mol Pharmacol. 2016 Dec;90(6):766-774.

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PF-06761281 (PF 06761281, PF06761281)

生物&药学活性

物理化学性质&存储条件

参考文献

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PF-06761281 (PF 06761281, PF06761281)

生物&药学活性

物理化学性质&存储条件

参考文献

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