PF-06747775 |Cas:1776112-90-3 Buy PF-06747775 from ProbeChem, Global Biochemicals Supplier

Chemical Structure : PF-06747775

CAS No.: 1776112-90-3

加入收藏

PF-06747775 (Mavelertinib;PF06747775)

货号: PC-60295Not For Human Use, Lab Use Only.

Mavelertinib (PF-06747775) is a potent, selective, irreversible EGFR mutants with IC50 of 12, 3, 4 and 5 nM for EGFR L858R-T790M, Del-T790M, L858R, and EGFR Del, respectively.

规格	价格	库存
10 mg	￥4580	In stock
50 mg	￥12800	In stock
100 mg	￥19800	In stock
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Mavelertinib (PF-06747775) is a potent, selective, irreversible EGFR mutants with IC50 of 12, 3, 4 and 5 nM for EGFR L858R-T790M, Del-T790M, L858R, and EGFR Del, respectively.
PF-06747775 displays excellent selectivity over wild-type EGFR (IC50=307 nM), and desirable ADME properties.
PF-06747775 shows potential for treatment of EGFR T790M mutation in advanced NSCLC.

物理化学性质&存储条件

分子量	415.433
分子式	C18H22FN9O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((3R,4R)-4-fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidin-3-yl)acrylamide

参考文献

1. Planken S, et al. J Med Chem. 2017 Apr 13;60(7):3002-3019.

2. Patel H, et al. Eur J Med Chem. 2017 May 11. pii: S0223-5234(17)30388-4.

3. Wang S, et al. J Hematol Oncol. 2016 Apr 12;9:34.

PF-06747775 (Mavelertinib;PF06747775)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

PF-06747775 (Mavelertinib;PF06747775)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.