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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-ROR-PF-06747711
PF-06747711

Chemical Structure : PF-06747711

CAS No.: 1892576-58-7

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PF-06747711 (PF06747711)

货号: PC-35596Not For Human Use, Lab Use Only.

PF-06747711 (PF06747711) is a potent, selective, orally bioavailable RORC2 (RORγt) inverse agonist with IC50 of 4.1 nM.

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10 mg ￥980 In stock
25 mg ￥1680 In stock
50 mg ￥2580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PF-06747711 (PF06747711) is a potent, selective, orally bioavailable RORC2 (RORγt) inverse agonist with IC50 of 4.1 nM.
PF-06747711 inhibits IL-17A production by human Th17 cells with IC50 of 9.5 nM.
PF-06747711 reduce levels of IL-17A in vivo after oral dosing in mice and corresponding reduction in skin inflammation.

物理化学性质&存储条件

分子量 497.522
分子式 C26H26F3N5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-Cyano-N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide

参考文献

1. Schnute ME, et al. J Med Chem. 2018 Aug 21. doi: 10.1021/acs.jmedchem.8b00392.

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