PF-06685249 |CAS:1467059-70-6 Probechem Biochemicals

Chemical Structure : PF-06685249

CAS No.: 1467059-70-6

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PF-06685249 (PF06685249, PF-249)

货号: PC-62774Not For Human Use, Lab Use Only.

PF-06685249 (PF06685249, PF-249) is a novel potent, orally active, α1β1γ1/α2β1γ1-isoform selective AMPK activator with Kd of 14 nM, EC50 of 12 nM for α1β1γ1-AMPK.

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5 mg	￥2280	In stock
10 mg	￥3580	In stock
25 mg	￥5580	In stock
100 mg		Get quote

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生物&药学活性

PF-06685249 (PF06685249, PF-249) is a novel potent, orally active, α1β1γ1/α2β1γ1-isoform selective AMPK activator with Kd of 14 nM, EC50 of 12 nM for α1β1γ1-AMPK.
PF-06685249 (PF06685249, PF-249) shows minimal activity at the β2-containing isoforms (α1β2γ1, α2β2γ1, α2β2γ3).
PF-06685249 (PF06685249, PF-249) demonstrates in vivo target engagement experiment in ZSF-1 rats, an obese/diabetic rodent model of diabetic nephropathy.

物理化学性质&存储条件

分子量	345.783
分子式	C17H16ClN3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-Chloro-5-(6-(dimethylamino)-2-methoxypyridin-3-yl)-1H-indole-3-carboxylic acid

参考文献

1. Edmonds DJ, et al. J Med Chem. 2018 Feb 28. doi: 10.1021/acs.jmedchem.7b01641.

PF-06685249 (PF06685249, PF-249)

生物&药学活性

物理化学性质&存储条件

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PF-06685249 (PF06685249, PF-249)

生物&药学活性

物理化学性质&存储条件

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