PF-06679142 |CAS:1467059-66-0 Probechem Biochemicals

Chemical Structure : PF-06679142

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PF-06679142 (PF06679142)

货号: PC-62773Not For Human Use, Lab Use Only.

PF-06679142 is a novel potent, orally active, α1β1γ1/α2β1γ1-isoform selective AMPK activator with Kd of 14 nM, EC50 of 22 nM for α1β1γ1-AMPK.

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生物&药学活性

PF-06679142 is a novel potent, orally active, α1β1γ1/α2β1γ1-isoform selective AMPK activator with Kd of 14 nM, EC50 of 22 nM for α1β1γ1-AMPK.
PF-06679142 shows minimal activity at the β2-containing isoforms (α1β2γ1, α2β2γ1, α2β2γ3).
PF-06679142 demonstrates in vivo target engagement experiment in ZSF-1 rats, an obese/diabetic rodent model of diabetic nephropathy.

物理化学性质&存储条件

分子量	357.357
分子式	C20H17F2NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4,6-difluoro-5-(4-(tetrahydro-2H-pyran-2-yl)phenyl)-1H-indole-3-carboxylic acid

参考文献

1. Edmonds DJ, et al. J Med Chem. 2018 Feb 28. doi: 10.1021/acs.jmedchem.7b01641.

PF-06679142 (PF06679142)

生物&药学活性

物理化学性质&存储条件

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PF-06679142 (PF06679142)

生物&药学活性

物理化学性质&存储条件

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