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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Sodium Channel-PF-06526290
PF-06526290

Chemical Structure : PF-06526290

CAS No.:

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PF-06526290 (PF06526290)

货号: PC-35154Not For Human Use, Lab Use Only.

PF-06526290 is a potent, selective Nav1.3 inhibitor with IC50 of 5.1 uM, interact with the Domain 4 voltage sensor domain (D4 VSD and shows no activity for Nav1.7.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    PF-06526290 is a potent, selective Nav1.3 inhibitor with IC50 of 5.1 uM, interact with the Domain 4 voltage sensor domain (D4 VSD and shows no activity for Nav1.7.

    物理化学性质&存储条件

    分子量 402.487
    分子式 C18H18N4O3S2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(3-benzyl-3-methylureido)-N-(thiazol-2-yl)benzenesulfonamide

    参考文献

    1. Wang L, et al. Br J Pharmacol. 2015 Oct;172(20):4905-18.

    2. Wang L, et al. Br J Pharmacol. 2018 May 23. doi: 10.1111/bph.14338.

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