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首页-小分子抑制剂&激动剂-GPCR-mGluR-PF-06462894
PF-06462894

Chemical Structure : PF-06462894

CAS No.: 1622291-66-0

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PF-06462894 (PF 06462894, PF06462894)

货号: PC-61058Not For Human Use, Lab Use Only.

PF-06462894 is a potent, subtype-selective mGluR5 negative allosteric modulator with Ki of 6.1 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    PF-06462894 is a potent, subtype-selective mGluR5 negative allosteric modulator with Ki of 6.1 nM.
    PF-06462894 possesses favorable properties and a predicted low clinical dose (2 mg twice daily).
    PF-06462894 does not show any evidence of immune activation in a mouse drug allergy model.

    物理化学性质&存储条件

    分子量 329.4
    分子式 C18H23N3O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one

    参考文献

    1. Stepan AF, et al. J Med Chem. 2017 Sep 28;60(18):7764-7780.

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