PF-06459988 |Cas:1428774-45-1 Buy PF-06459988 from ProbeChem, Global Biochemicals Supplier

Chemical Structure : PF-06459988

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PF-06459988 (PF 06459988;PF06459988;PF 6459988)

货号: PC-60296Not For Human Use, Lab Use Only.

PF-06459988 (PF06459988, PF 6459988) is a potent, selective, irreversible EGFR mutants with IC50 of 13, 7, 21 and 90 nM for EGFR L858R-T790M, Del-T790M, L858R, and EGFR Del, respectively.

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1 g		Get quote

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生物&药学活性

PF-06459988 (PF06459988, PF 6459988) is a potent, selective, irreversible EGFR mutants with IC50 of 13, 7, 21 and 90 nM for EGFR L858R-T790M, Del-T790M, L858R, and EGFR Del, respectively; exhibist selectivity over wild-type EGFR (IC50>5 uM); shows potential for treatment of EGFR T790M mutation in advanced NSCLC.

Lung Cancer

Phase 1 Discontinued

物理化学性质&存储条件

分子量	431.88
分子式	C19H22ClN7O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-[(3R,4R)-3-[[[5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]methyl]-4-methoxy-1-pyrrolidinyl]-2-propen-1-one

参考文献

1. Cheng H, et al. J Med Chem. 2016 Mar 10;59(5):2005-24.

2. Planken S, et al. J Med Chem. 2017 Apr 13;60(7):3002-3019.

PF-06459988 (PF 06459988;PF06459988;PF 6459988)

生物&药学活性

物理化学性质&存储条件

参考文献

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PF-06459988 (PF 06459988;PF06459988;PF 6459988)

生物&药学活性

物理化学性质&存储条件

参考文献

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