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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Diglyceride Acyltransferase (DGAT)-PF-06424439
PF-06424439

Chemical Structure : PF-06424439

CAS No.: 1469284-78-3

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PF-06424439 (PF06424439)

货号: PC-38095Not For Human Use, Lab Use Only.

PF-06424439 (PF06424439) is a potent, selective, orally acitve DGAT2 inhibitor with IC50 of 14 nM.

规格 价格 库存 数量
10 mg ￥1580 In stock
25 mg ￥2580 In stock
50 mg ￥4280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PF-06424439 (PF06424439) is a potent, selective, orally acitve DGAT2 inhibitor with IC50 of 14 nM.
PF-06424439 displays no significant activity at MGAT1-3 or DGAT1.
PF-06424439 reduces triglyderide synthesis in human hepatocytes in vitro.
PF-06424439 reduces plasma triglyceride and cholesterol levels in a rat dyslipidemia model.

物理化学性质&存储条件

分子量 39.94
分子式 C22H26ClN7O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-(1-(2-(1-(4-chloro-1H-pyrazol-1-yl)cyclopropyl)-3H-imidazo[4,5-b]pyridin-5-yl)piperidin-3-yl)(pyrrolidin-1-yl)methanone

参考文献

1. Futatsugi K, et al. J Med Chem. 2015 Sep 24;58(18):7173-85.

2. Pabst B, et al. Biochemistry. 2018 Dec 26;57(51):6997-7010.

3. Takemoto K, et al. Physiol Rep. 2020 Aug;8(15):e14542.

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