PF 6260933 dihydrochloride |CAS:1883548-86-4 Probechem Biochemicals

Chemical Structure : PF-06260933 dihydrochloride

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PF-06260933 dihydrochloride (PF 06260933 dihydrochloride)

货号: PC-61694Not For Human Use, Lab Use Only.

PF-06260933 dihydrochloride is a potent, selective and orally bioavailable MAP4K4 inhibitor with kinase IC50 of 3.7 nM, cell IC50 of 160 nM.

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生物&药学活性

PF-06260933 dihydrochloride is a potent, selective and orally bioavailable MAP4K4 inhibitor with kinase IC50 of 3.7 nM, cell IC50 of 160 nM.
PF-06260933 dihydrochloride possesses excellent kinome selectivity and suitable properties for in vivo pharmacological characterization.
PF-06260933 dihydrochloride significantly improves fasting hyperglycemia (44% reduction in blood glucose, 10 mg/kg, bid); also markedly reduces atherosclerotic lesion area in mice.

物理化学性质&存储条件

分子量	369.67
分子式	C16H15Cl3N4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(4-Chlorophenyl)-[3,3'-bipyridine]-6,6'-diamine dihydrochloride

参考文献

1. Ammirati M, et al. ACS Med Chem Lett. 2015 Oct 6;6(11):1128-33.

2. Roth Flach RJ, et al. Nat Commun. 2015 Dec 21;6:8995.

PF-06260933 dihydrochloride (PF 06260933 dihydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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PF-06260933 dihydrochloride (PF 06260933 dihydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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