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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-MAP4K-PF-06260933
PF-06260933

Chemical Structure : PF-06260933

CAS No.: 1811510-56-1

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PF-06260933 (PF 6260933;PF6260933)

货号: PC-60014Not For Human Use, Lab Use Only.

PF-06260933 (PF06260933,PF6260933) is a potent, selective, orally available MAP4K4 inhibitor with IC50 of 3.7 nM.

规格 价格 库存 数量
5 mg ￥980 In stock
10 mg ￥1580 In stock
25 mg ￥2780 In stock
50 mg ￥4580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PF-06260933 (PF06260933, PF6260933) is a potent, selective, orally available MAP4K4 inhibitor with IC50 of 3.7 nM.
PF-06260933 demonstrates very good selectivity against more than 150 native kinases, with only the closely related GCK family members (ZC2, TNIK and ZC3, MINK 70% inhibition at 1 uM).
PF-06260933 inhibits LPS-induced plasma TNFα levels in mouse model.

物理化学性质&存储条件

分子量 296.754
分子式 C16H13ClN4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-(4-chlorophenyl)-[3,3'-bipyridine]-6,6'-diamine

参考文献

1. Ammirati M, et al. ACS Med Chem Lett. 2015 Oct 6;6(11):1128-33.

2. Roth Flach RJ, et al. Nat Commun. 2015 Dec 21;6:8995.

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