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首页-小分子抑制剂&激动剂-Immunology/Inflammation-IRAK-PF-05388169
PF-05388169

Chemical Structure : PF-05388169

CAS No.: 1604034-78-7

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PF-05388169 (PF 05388169, PF05388169)

货号: PC-61091Not For Human Use, Lab Use Only.

PF-05388169 is a potent, selective IRAK4 inhibitor with IC50 of 0.094 nM, >500-fold selectivity over IRAK1 (IC50=65 nM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    PF-05388169 is a potent, selective IRAK4 inhibitor with IC50 of 0.094 nM, >500-fold selectivity over IRAK1 (IC50=65 nM).
    PF-05388169 exhibits low nM potency in LPS- and R848-induced cytokine assays (IC50=85 nM) in human PBMCs.
    PF-05388169 inhibits LPS-induced TNFα in an in vivo murine model.

    物理化学性质&存储条件

    分子量 391.427
    分子式 C22H21N3O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    11H-Indolo[3,2-c]quinoline-9-carbonitrile, 2-methoxy-3-[2-(2-methoxyethoxy)ethoxy]-

    参考文献

    1. Lai CY, et al. J Immunol Res. 2017;2017:7807313.

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