PF-05387252 |CAS:1604034-71-0 Probechem Biochemicals

Chemical Structure : PF-05387252

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PF-05387252 (PF 05387252;PF05387252)

货号: PC-61092Not For Human Use, Lab Use Only.

A potent, selective IRAK4 inhibitor with IC50 of 1.3 nM, 200-fold selectivity over IRAK1 (IC50=290 nM).

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生物&药学活性

PF-05387252 is a potent, selective IRAK4 inhibitor with IC50 of 1.3 nM, 200-fold selectivity over IRAK1 (IC50=290 nM).
PF-05387252 exhibits low nM potency in LPS- and R848-induced cytokine assays (IC50=18 nM) in human PBMCs.
PF-05387252 inhibits LPS-induced TNFα in an in vivo murine model.

物理化学性质&存储条件

分子量	429.524
分子式	C25H27N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	11H-Indolo[3,2-c]quinoline-9-carbonitrile, 2-methoxy-3-[3-(4-methyl-1-piperazinyl)propoxy]-

参考文献

1. Lai CY, et al. J Immunol Res. 2017;2017:7807313.

2. Tumey LN, et al. Bioorg Med Chem Lett. 2014 May 1;24(9):2066-72.

PF-05387252 (PF 05387252;PF05387252)

生物&药学活性

物理化学性质&存储条件

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PF-05387252 (PF 05387252;PF05387252)

生物&药学活性

物理化学性质&存储条件

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