PF-05221304 (Clesacostat) | ACC inhibitor | Probechem Biochemicals

Chemical Structure : PF-05221304

CAS No.: 1370448-25-1

加入收藏

PF-05221304 (Clesacostat, PF 05221304)

货号: PC-72388Not For Human Use, Lab Use Only.

PF-05221304 (PF 05221304) is a novel potent, selective, liver-targeted dual acetyl-CoA carboxylase (ACC1/2) inhibitor with IC50 of 13/9 nM (hACC1/2).

规格	价格	库存
5 mg	￥2180	In stock
10 mg	￥3580	In stock
25 mg	￥5580	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

PF-05221304 (Clesacostat) is a novel potent, selective, liver-targeted dual acetyl-CoA carboxylase (ACC1/2) inhibitor with IC50 of 13/9 nM (hACC1/2).
PF-05221304 displays no inhibition against a panel of e 5'-diphospho-glucuronosyltransferase (UGT) enzymes at 20 uM, as well as a broad panel of transporters, receptors, ion channels and enzymes, including the hERG channel.
PF-05221304 dose-dependently causes reductions in liver de novo lipogenesis (DNL) with a maximal reduction of 82% (EC50=5.4 nM) at 300 mg/kg (p.o.), weak DNL inhibition in lung and bone marrow.

物理化学性质&存储条件

分子量	502.571
分子式	C28H30N4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-(1-isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carbonyl)-6-methoxypyridin-2-yl)benzoic acid

参考文献

1. Huard K, et al. J Med Chem. 2020 Oct 8;63(19):10879-10896.

2. Calle RA, et al. Nat Med. 2021 Oct;27(10):1836-1848.

3. Ross TT, et al. Cell Mol Gastroenterol Hepatol. 2020;10(4):829-851.

PF-05221304 (Clesacostat, PF 05221304)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

PF-05221304 (Clesacostat, PF 05221304)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.