PF-05190457 (PF-5190457) | GHSR inverse agonist | Probechem Biochemicals

Chemical Structure : PF-05190457

CAS No.: 1334782-79-4

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PF-05190457 (PF05190457, PF-5190457, PF5190457)

货号: PC-61098Not For Human Use, Lab Use Only.

PF-05190457 (PF-5190457) is a potent, selective, and orally bioavailable ghrelin receptor (GHSR) inverse agonist with binding pKi of 8.36.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

PF-05190457 (PF-5190457) is a potent, selective, and orally bioavailable ghrelin receptor (GHSR) inverse agonist with binding pKi of 8.36.
PF-05190457 displays excellent off-target activity in the CEREP panel at 10 uM with exception of serotonin 5-HT2B (IC50=3.7 uM).
PF-05190457 demonstrates robust increases in glucose-stimulated insulin secretion in human islets.

物理化学性质&存储条件

分子量	512.676
分子式	C29H32N6OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMS) >400 mM /mL (200 mg/mL) Ethanol: 200 mM/mL (103.2 mg/mL)
Chemical Name/SMILES	(R)-2-(2-methylimidazo[2,1-b]thiazol-6-yl)-1-(2-(5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl)-2,7-diazaspiro[3.5]nonan-7-yl)ethan-1-one

参考文献

1. Bhattacharya SK, et al. ACS Med Chem Lett. 2014 Feb 24;5(5):474-9.

2. Kong J, et al. Br J Pharmacol. 2016 May;173(9):1452-64.

3. Denney WS, et al. Br J Clin Pharmacol. 2017 Feb;83(2):326-338.

PF-05190457 (PF05190457, PF-5190457, PF5190457)

生物&药学活性

物理化学性质&存储条件

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询单

PF-05190457 (PF05190457, PF-5190457, PF5190457)

生物&药学活性

物理化学性质&存储条件

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