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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Acetyl-CoA Carboxylase (ACC)-PF-05175157
PF-05175157

Chemical Structure : PF-05175157

CAS No.: 1301214-47-0

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PF-05175157 (PF05175157;PF-5175157)

货号: PC-63466Not For Human Use, Lab Use Only.

PF-05175157 (PF-5175157) is a potennt Acetyl-CoA carboxylase (ACC) inhibitor with IC50 of 27 and 33 nM for hAAC1 and hACC2, respectively.

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25 mg ￥2480 In stock
100 mg ￥6580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PF-05175157 (PF-5175157) is a potennt Acetyl-CoA carboxylase (ACC) inhibitor with IC50 of 27 and 33 nM for hAAC1 and hACC2, respectively.
PF-05175157 shows concentration-dependent reductions in both skeletal muscle and liver malonyl-CoA with EC50 of 870 and 540 nM after 1 h following an acute oral dose in rats.
PF-05175157 demonstrates significant potential for the treatment of type 2 diabetes mellitus (T2DM).

物理化学性质&存储条件

分子量 405.49
分子式 C23H27N5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1,4-Dihydro-1'-[(2-methyl-1H-benzimidazol-6-yl)carbonyl]-1-(1-methylethyl)spiro[5H-indazole-5,4'-piperidin]-7(6H)-one

参考文献

1. Griffith DA, et al. J Med Chem. 2014 Dec 26;57(24):10512-26.

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