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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Phosphodiesterase (PDE)-PF-05085727
PF-05085727

Chemical Structure : PF-05085727

CAS No.: 1415637-72-7

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PF-05085727 (PF 05085727, PF05085727)

货号: PC-61126Not For Human Use, Lab Use Only.

PF-05085727 is a potent, selective, brain penetrant phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 2 nM, >4,000-fold selectivity over PDE1 and PDE3-11.

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5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥2180 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PF-05085727 is a potent, selective, brain penetrant phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 2 nM, >4,000-fold selectivity over PDE1 and PDE3-11.
PF-05085727 increases brain cGMP accumulation in rodent brain regions expressing highest levels of PDE2A.
PF-05085727 demonstrates in vivo activity for clinical cognition indications.

物理化学性质&存储条件

分子量 413.408
分子式 C20H18F3N7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(Azetidin-1-yl)-1-methyl-3-(1-methyl-5-(4-(trifluoromethyl)-phenyl)-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidine

参考文献

1. Helal CJ, et al. J Med Chem. 2017 Jul 13;60(13):5673-5698.

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