PF-04995274 (PF-4995274, TBPT)

Chemical Structure : PF-04995274

CAS No.: 1331782-27-4

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货号: PC-61831Not For Human Use, Lab Use Only.

PF-04995274 (PF-4995274, TBPT) is a potent, selective, orally active and partial serotonin 4 receptor (5-HT4R) agonist with Ki of 0.15-0.46 nM.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

PF-04995274 (PF-4995274, TBPT) is a potent, selective, orally active and partial serotonin 4 receptor (5-HT4R) agonist with Ki of 0.15-0.46 nM.

PF-04995274 exhibits an EC50 range of 0.26-0.47 nM for human 5-HT4A/4B/4D/4E and 0.59-0.65 nM for rat 5-HT4S/4L/4E.

PF-04995274 (3-10 mg/kg, i.v.) treatment results in prophylactic efficacy by attenuating learned fear and decreasing stress-induced depressive-like behavior in mice.

PF-04995274 is brain penetrant for investigation of cognitive disorders associated with Alzheimer's disease.

物理化学性质&存储条件

分子量	432.5214
分子式	C23H32N2O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 100 mg/mL
Chemical Name/SMILES	(R)-4-((4-(((4-(Tetrahydrofuran-3-yloxy)-1,2-benzisoxazol-3-yl)oxy)methyl)piperidin-1-yl)methyl)tetrahydro-2H-pyran-4-ol

参考文献

1. Sawant-Basak A, et al. J Pharm Sci. 2013 Sep;102(9):3277-93.